Search results for "Stress path"
showing 5 items of 5 documents
Exacerbation of adverse cardiovascular effects of aircraft noise in an animal model of arterial hypertension
2020
Arterial hypertension is the most important risk factor for the development of cardiovascular disease. Recently, aircraft noise has been shown to be associated with elevated blood pressure, endothelial dysfunction, and oxidative stress. Here, we investigated the potential exacerbated cardiovascular effects of aircraft noise in combination with experimental arterial hypertension. C57BL/6J mice were infused with 0.5 mg/kg/d of angiotensin II for 7 days, exposed to aircraft noise for 7 days at a maximum sound pressure level of 85 dB(A) and a mean sound pressure level of 72 dB(A), or subjected to both stressors. Noise and angiotensin II increased blood pressure, endothelial dysfunction, oxidati…
Metformin increases APP expression and processing via oxidative stress, mitochondrial dysfunction and NF-κB activation: Use of insulin to attenuate m…
2015
AbstractClinical and experimental biomedical studies have shown Type 2 diabetes mellitus (T2DM) to be a risk factor for the development of Alzheimer's disease (AD). This study demonstrates the effect of metformin, a therapeutic biguanide administered for T2DM therapy, on β-amyloid precursor protein (APP) metabolism in in vitro, ex vivo and in vivo models. Furthermore, the protective role of insulin against metformin is also demonstrated. In LAN5 neuroblastoma cells, metformin increases APP and presenilin levels, proteins involved in AD. Overexpression of APP and presenilin 1 (Pres 1) increases APP cleavage and intracellular accumulation of β-amyloid peptide (Aβ), which, in turn, promotes ag…
Shear strength of a compacted scaly clay in variable saturation conditions
2015
Scaly clays are stiff and highly fissured clays often used as construction materials. This paper presents the results of triaxial compression tests carried out on saturated and unsaturated samples of a compacted scaly clay. Complementary investigation on the microstructural features and their evolution with the amount of water stored into the material are also presented in order to shed light on the evolution of the micro- and macroporosity with suction. The water retention behaviour of the compacted scaly clay is also addressed. The results from the controlled suction triaxial tests are used to discuss the applicability of a single-shear strength criterion to compacted double-structured cl…
Stress path dependence of hydromechanical behaviour of compacted scaly clay in wetting and drying suction controlled oedometer tests at constant vert…
2008
The results are presented of an experimental programme devoted to investigating the volumetric strain and water ratio (volume of water to volume of solids) evolution of a compacted scaly clay stressed by wetting and drying cycles in suction-controlled oedometer tests. The stress paths applied included loading and unloading cycles at constant matric suction and suction controlled wetting-drying cycles at constant vertical net stress. The test results show that during wetting and drying cycles the samples experienced irreversible shrinkage or swelling strains depending on the stress path applied. Irreversible water ratio increases were always observed in these cycles. However, a quasi-reversi…
Shot-clay MX-80 bentonite: An assessment of the hydro-mechanical behaviour
2014
This study presents the results of an experimental study conducted to characterise the hydro-mechanical behaviour of shot-clay MX-80 bentonite. In the shot-clay process, granular bentonite was mixed continuously with water and shot on the walls of a tunnel section at the Grimsel Underground Research Laboratory (URL), in Switzerland. The shot-clay was placed to create a layer of bentonite in direct contact with the host rock to avoid preferential water and/or gas flow along the tunnel wall. Samples for an experimental programme were collected during the shooting. The index properties, microstructural features, swelling potential and water retention properties of the shot-clay were analysed. …